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Updated: Jul 2, 2026
Intrastriatal Injection of Autologous Blood or Clostridial Collagenase as Murine Models of Intracerebral Hemorrhage
Published on: July 3, 2014
From bench to bedside: nanomedicine development for intracerebral hemorrhage - exploring microenvironment,
Gui Wan1, Lingui Gu1, Yangyang Chen2
1Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.
Insights
Intracerebral hemorrhage (ICH) causes significant disability. Nanomedicines show promise for treating ICH by targeting brain microenvironment changes like inflammation and oxidative stress, offering new therapeutic avenues.
Area of Science:
- Neuroscience
- Biomedical Engineering
- Pharmacology
Background:
- Intracerebral hemorrhage (ICH) presents a major global health challenge with severe prognoses.
- Secondary injury mechanisms in ICH involve complex molecular pathways affecting the brain microenvironment (BME).
- Current ICH treatments have limitations, necessitating novel therapeutic strategies.
Purpose of the Study:
- To review the mechanisms of BME alteration in ICH, focusing on angiogenesis, inflammation, and oxidative stress (OS).
- To outline conventional ICH diagnostics and therapeutics, highlighting their drawbacks.
- To systematically summarize nanomedicine research targeting the post-ICH BME and analyze clinical translation.
Main Methods:
- Literature review of ICH pathophysiology, focusing on BME changes.
- Analysis of conventional diagnostic and therapeutic approaches for ICH.
- Systematic review of nanomedicine applications for angiogenesis, inflammation, and OS in ICH, including clinical translation.
Main Results:
- ICH significantly alters the BME through angiogenesis, inflammation, and OS.
- Conventional ICH treatments offer limited efficacy and possess drawbacks.
- Nanomedicines demonstrate potential in modulating these BME factors, with ongoing clinical translation efforts.
Conclusions:
- Nanomedicines represent a promising therapeutic strategy for ICH by targeting key BME alterations.
- Further research and clinical translation are crucial for realizing the full potential of nanomedicines in ICH treatment.
- Addressing challenges in nanomedicine delivery and efficacy is key for future applications in ICH management.
Abstract:
Intracerebral hemorrhage (ICH) carries a substantial global disease burden, and although it occurs less frequently than ischemic stroke, it results in a greater loss of disability-adjusted life years worldwide and is associated with one of the poorest prognoses among stroke patients. Due to the mechanisms of secondary injury following ICH, angiogenesis, inflammation, and oxidative stress (OS) levels in brain tissue are regulated by complex molecular pathways, leading to significant changes in the brain microenvironment (BME). While traditional treatments for ICH improve survival rates, they have notable drawbacks and limitations. Nanomedicines, as a promising approach, offer the potential to gradually overcome these limitations and are becoming increasingly important in ICH treatment research. This review provides an updated overview of the mechanisms behind the formation of the post-ICH BME, focusing on angiogenesis, inflammation, and OS. Conventional diagnostic and therapeutic methods are outlined, along with an analysis of their drawbacks and limitations. In addition, the current research status of nanomedicines targeting the post-ICH BME is systematically summarized from three perspectives: angiogenesis, inflammation, and OS. Finally, the progress of nanomedicines in clinical translation is analyzed, highlighting the challenges, opportunities, and future prospects for their application in the context of ICH.
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