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Updated: Sep 11, 2025

Extracellular Glucose Depletion as an Indirect Measure of Glucose Uptake in Cells and Tissues Ex Vivo
Published on: April 6, 2022
FluMag-SELEX derived specific individual aptamers can fluorescently label the ageing immanent protein-crosslinker
Runliu Li1, Bastian Draphoen2, Mika Lindén2
1Institute of Pharmaceutical Biotechnology, Ulm University, Albert-Einstein-Allee 11, 89081 Ulm, Germany. ann-kathrin.kissmann@uni-ulm.de.
Abstract:
Nowadays, aptamers have transitioned into valuable antibody alternatives. We present the first anti-glucosepane aptamer targeting a key glycation product linked to aging and diabetes. Glu3, with high specificity and affinity, enabled the first-ever direct, fluorescence-based histological staining of glucosepane in murine tissue, distinguishing diabetic samples from wild-type samples without secondary reagents.

