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Updated: Sep 11, 2025

Isolation and Culture Expansion of Tumor-specific Endothelial Cells
Published on: October 14, 2015
Linking tumour angiogenesis and tumour immunity
Ashraf Ul Kabir1,2, Madhav Subramanian1,3, Yoojung Kwon1
1Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Immune checkpoint blockade therapy shows promise for cancer treatment, but many patients do not respond. Understanding tumour angiogenesis and its link to immune responses is crucial for improving immunotherapy efficacy.
Area of Science:
- Oncology
- Immunology
- Vascular Biology
Background:
- Immune checkpoint blockade (ICB) therapy has transformed cancer treatment, yet response rates remain limited.
- Tumour-associated blood vessel abnormalities hinder immune cell infiltration and create an immunosuppressive tumour microenvironment.
- There is an inverse correlation between tumour angiogenesis and anti-tumour immune activity.
Purpose of the Study:
- To review the role of tumour angiogenesis in tumour immunity and its impact on immunotherapy outcomes.
- To explore the molecular mechanisms governing the interplay between angiogenesis and tumour immunity.
- To discuss novel anti-angiogenic strategies for combination therapy in cancer treatment.
Main Methods:
- Literature review integrating preclinical and clinical studies.
- Analysis of molecular mechanisms of angiogenesis-immunity crosstalk.
- Discussion of emerging anti-angiogenic regulators.
Main Results:
- Tumour angiogenesis significantly influences tumour progression and response to immunotherapy.
- Dysfunctional tumour vasculature impairs the efficacy of anti-cancer immune responses.
- Emerging anti-angiogenic agents show potential for enhancing immunotherapy.
Conclusions:
- Targeting tumour angiogenesis is a promising strategy to overcome resistance to immune checkpoint blockade.
- Combination therapies involving anti-angiogenic agents and immunotherapy may improve patient outcomes.
- Further research is needed to optimize combined therapeutic approaches for enhanced cancer treatment.
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