Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Skin Cancer01:30

Skin Cancer

4.5K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
4.5K
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

5.4K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
5.4K
Papillary Dermis01:11

Papillary Dermis

3.4K
Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...
3.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Successful management of refractory hyperprolactinemia secondary to ectopic prolactin-secreting disseminated peritoneal leiomyomatosis via surgical resection and postoperative leuprorelin therapy: a rare case report.

Gynecology and pelvic medicine·2026
Same author

Comprehensive quality evaluation of ultrasound-assisted fermented Yuluxiang pear juice: Physicochemical characteristics, antioxidant activity, and multi-dimensional flavor analysis.

Ultrasonics sonochemistry·2026
Same author

Mechanically Adaptive Polyimide Interfaces for Stable High-Voltage NCM-Sulfide All-Solid-State Batteries.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Trinity Cooperative Electrode as a High-Performance Electrocatalytic Host for Ultra-Stable, High-Rate Zinc-Halogen Batteries.

Angewandte Chemie (International ed. in English)·2026
Same author

Membrane receptor TGR5 upregulates IP3R-induced calcium overload: Key mechanism of bile acid-induced acute pancreatitis.

Cellular signalling·2026
Same author

Ovarian Sertoli-Leydig cell tumors with somatic DICER1 mutations: a clinicopathologic study of 15 cases.

American journal of cancer research·2026

Related Experiment Video

Updated: Sep 11, 2025

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia
06:15

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

1.4K

Vulvar dermatofibrosarcoma protuberans: a case series.

Chuan Xie1,2, Yangmei Shen2,3

  • 1Department of Gynecology and Obstetrics, West China Second University Hospital, Sichuan University Chengdu, Sichuan, P. R. China.

American Journal of Cancer Research
|August 15, 2025
PubMed
Summary
This summary is machine-generated.

Dermatofibrosarcoma protuberans (DFSP) of the vulva is rare, often presenting as asymptomatic masses. Wide local excision with negative margins is the primary treatment, significantly reducing the risk of recurrence.

Keywords:
Dermatofibrosarcoma protuberansMohs micrographic surgerycase seriesvulvawide local excision

More Related Videos

Stromal Vascular Fraction-enriched Fat Grafting for the Treatment of Symptomatic End-neuromata
07:58

Stromal Vascular Fraction-enriched Fat Grafting for the Treatment of Symptomatic End-neuromata

Published on: November 23, 2017

7.8K
Isolation, Culture, and Characterization of Prostate Cancer-Associated Fibroblasts
09:43

Isolation, Culture, and Characterization of Prostate Cancer-Associated Fibroblasts

Published on: August 1, 2025

183

Related Experiment Videos

Last Updated: Sep 11, 2025

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia
06:15

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

1.4K
Stromal Vascular Fraction-enriched Fat Grafting for the Treatment of Symptomatic End-neuromata
07:58

Stromal Vascular Fraction-enriched Fat Grafting for the Treatment of Symptomatic End-neuromata

Published on: November 23, 2017

7.8K
Isolation, Culture, and Characterization of Prostate Cancer-Associated Fibroblasts
09:43

Isolation, Culture, and Characterization of Prostate Cancer-Associated Fibroblasts

Published on: August 1, 2025

183

Area of Science:

  • Oncology
  • Dermatology
  • Gynecologic Oncology

Background:

  • Dermatofibrosarcoma protuberans (DFSP) is a rare, low-to-intermediate grade sarcoma.
  • DFSP typically affects the trunk and extremities, with vulvar involvement being exceptionally rare.
  • The clinical characteristics and management of vulvar DFSP are poorly understood due to its rarity.

Observation:

  • A retrospective analysis of seven vulvar DFSP cases between January 2010 and January 2023 was conducted.
  • Patients presented with firm, asymptomatic masses, most commonly on the labia majora, with an average tumor size of 4.3 cm.
  • The median age at symptom onset was 44.3 years, predominantly affecting young to middle-aged women.

Findings:

  • All patients underwent wide local excision; none received lymphadenectomy.
  • Five out of six patients achieved negative surgical margins after initial wide excision.
  • A local recurrence rate of 14.3% was observed, with no recurrence in patients who achieved negative margins.

Implications:

  • Wide local excision is the primary treatment modality for vulvar DFSP.
  • Achieving widely negative surgical margins is crucial for preventing local recurrence.
  • Long-term follow-up is recommended for patients with vulvar DFSP to monitor for potential recurrence.