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Related Concept Videos

Bioreactor Design and Operational System01:29

Bioreactor Design and Operational System

Bioreactors are engineered vessels designed to cultivate microorganisms under controlled conditions for industrial bioprocessing. They maintain sterility and allow precise regulation of pH, temperature, oxygen, and nutrient levels to optimize microbial growth and metabolite production. Bioreactors range from small laboratory units of 1 liter to industrial systems holding up to 500,000 liters, though only about 75% of their volume is actively used for fermentation. The remaining headspace...
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Maintaining optimal conditions within fermenters is essential for maximizing microbial productivity and ensuring process efficiency. This lesson focuses on key parameters—temperature, foam, pH, carbon dioxide, oxygen, and pressure—and their precise measurement and control strategies in fermentation systems.Temperature ControlTemperature regulation is critical due to the exothermic nature of many fermentation processes. In small laboratory fermenters, temperature is commonly monitored using...
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In aerobic fermentations, oxygen is vital for microbial growth and metabolite production. Since air comprises only about 20% oxygen and the gas is poorly soluble in water—just 9 ppm at 20°C—supplying sufficient oxygen becomes a critical challenge, especially in high-demand processes like yeast growth or citric acid production. Even a fully saturated broth may offer only a few seconds of oxygen availability.To address this, sterile or scrubbed air is introduced into the fermentor via a sparger...

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Modified bio-Bentall operation with a rapid deployment valve.

Hyo Kyen Park1, Hong Rae Kim1, Joon Bum Kim1

  • 1Department of Thoracic and Cardiovascular Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.

JTCVS Techniques
|August 15, 2025
PubMed
Summary

The modified bio-Bentall operation with a rapid deployment valve (RDV) shows promising early results in high-risk patients, with no early deaths or reoperations. Further studies are needed to confirm long-term efficacy.

Keywords:
Bentall operationparavalvular leakagerapid deployment valve

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Area of Science:

  • Cardiovascular Surgery
  • Thoracic Surgery
  • Surgical Innovation

Background:

  • The bio-Bentall operation is a complex procedure for aortic root and ascending aorta replacement.
  • High-risk patients often face increased operative risks with traditional valve replacement methods.
  • Rapid deployment valves (RDVs) offer potential advantages in reducing cross-clamp and bypass times.

Purpose of the Study:

  • To evaluate the early outcomes of a modified bio-Bentall operation utilizing an RDV.
  • To assess procedural efficacy, survival rates, and complications in high-risk patients.
  • To determine the safety and feasibility of this modified approach.

Main Methods:

  • Retrospective review of 11 consecutive high-risk patients undergoing the modified bio-Bentall operation with an RDV.
  • Analysis of baseline characteristics, operative details, and postoperative outcomes.
  • Kaplan-Meier survival analysis for survival rates.

Main Results:

  • No early mortality or reoperations were observed in the study cohort.
  • The 1-year survival rate was 90.9%, with a 3-year survival rate of 54.5%.
  • Complications included need for extracorporeal membrane oxygenation (14.3%) and permanent pacemaker insertion (23.1%).

Conclusions:

  • The modified bio-Bentall operation with an RDV demonstrates favorable early outcomes in high-risk surgical candidates.
  • The procedure appears safe and effective for initial management, with acceptable early complication rates.
  • Larger studies and extended follow-up are necessary to fully validate long-term results and safety profiles.