Related Experiment Video
Updated: Sep 11, 2025

An In Ovo Model for Testing Insulin-mimetic Compounds
Published on: April 23, 2018
A Structure-activity Relationship (SAR) Insight for the Most Effective Oral Antidiabetic Compounds-A Current Review
Fathiy Mutalabisin1, Nader Ghaffari Khaligh1
1Nanotechnology and Catalysis Research Center, Institute for Advanced Studies (IAS), Universiti Malaya, 50603 Kuala Lumpur, Malaysia.
Abstract:
Diabetes mellitus, a chronic metabolic disorder, poses a significant global health challenge, demanding continuous research into effective treatments. With projections of 629 million individuals affected by 2045 and escalating healthcare costs, the need for new anti-diabetic medications is urgent. Current therapies often present limitations, including undesirable side effects and insufficient long-term efficacy. This review explores the development of oral anti-diabetic drugs (OADs), focusing on the structure-activity relationship (SAR) employed to create both established and emerging classes of medications. We examine the six major OAD classes: biguanides, sulfonylureas, meglitinides, thiazolidinediones, DPP-4 inhibitors, and SGLT2 inhibitors. In addition, a new promising class of OAD, namely metal complexes, is discussed. This review highlights the crucial role of synthetic chemistry in advancing diabetes treatment and improving patient outcomes.
More Related Videos
07:30Homogeneous Time-resolved Förster Resonance Energy Transfer-based Assay for Detection of Insulin Secretion
Published on: May 10, 2018
09:31Sustained Administration of β-cell Mitogens to Intact Mouse Islets Ex Vivo Using Biodegradable Poly(lactic-co-glycolic acid) Microspheres
Published on: November 5, 2016
Related Concept Videos
Oral Hypoglycemic Agents: α-Glucosidase Inhibitors
Acarbose and miglitol are...
Oral Hypoglycemic Agents: Glinides
Oral Hypoglycemic Agents: Biguanides and Glitazones
Oral Hypoglycemic Agents: Sulfonylureas
Structure-Activity Relationships and Drug Design
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence...
Dipeptidyl Peptidase 4 Inhibitors