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Biomimetic Nanofluidic Devices: From Functionalization to Emerging Biomedical Applications
Ziyan Xue1, Chengcheng Zhu1, Jin Wang1
1State Key Laboratory of Microbial Technology, Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China.
Analytical Chemistry
|August 15, 2025
Summary
Biomimetic nanofluidic devices offer label-free biomedical analysis by mimicking biological systems. These advanced nanoplatforms are revolutionizing clinical diagnostics and drug screening through precise ion and molecular monitoring.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Biophysics
Background:
- Biomimetic nanofluidic devices leverage nanoconfinement effects for advanced biomedical analysis.
- These platforms enable label-free detection, crucial for sensitive biological assays.
- They offer precise monitoring of ionic dynamics, molecular interactions, and neural signals.
Purpose of the Study:
- To provide a comprehensive review of recent advancements in biomimetic nanofluidic technology for biomedical applications.
- To discuss innovative fabrication and surface functionalization strategies for nanofluidic devices.
- To summarize current applications and future perspectives in the field.
Main Methods:
- Review of innovative fabrication strategies and surface functionalization techniques.
- Systematic discussion of ion transport mechanisms in nanochannels.
- Summary of applications in clinical diagnostics, artificial synapses, neuromorphic computing, and drug screening.
Main Results:
- Recent advancements in biomimetic nanofluidic device engineering have been detailed.
- The review systematically covers ion transport and response mechanisms in nanochannels.
- Key applications in diagnostics, neuromorphic systems, and drug discovery are highlighted.
Conclusions:
- Biomimetic nanofluidic devices are powerful tools for label-free biomedical analysis.
- These technologies offer versatile solutions for clinical diagnostics, neuromorphic applications, and drug screening.
- Further research into rational design is crucial for high-performance biomimetic nanochannel applications.
