Diagnostic Value and Prognostic Effect of miR-7-5p in Cirrhosis

The purpose of this study was to examine miR-7-5p levels in patients with liver cirrhosis and its correlation with liver function, as well as to evaluate its clinical value as a diagnostic and prognostic biomarker.

miR-7-5p levels in 86 liver cirrhosis patients and 95 healthy volunteers were measured using qRT-PCR. Pearson correlation analysis was employed to calculate the relationship between miR-7-5p and liver function indicators (alanine aminotransferase [ALT], aspartate aminotransferase [AST], PT, INR, total bilirubin [TBil], and albumin). ROC curve was conducted to evaluate its diagnostic significance. Additionally, Cox regression analysis and the Kaplan-Meier method were utilized to evaluate the prognostic significance of miR-7-5p.

The findings revealed that miR-7-5p was upregulated in the serum liver cirrhosis patients. Its levels positively correlated with ALT (r = 0.319, p = 0.003), AST (r = 0.424, p < 0.001), PT (r = 0.357, p < 0.001), INR (r = 0.312, p = 0.003), TBil (r = 0.557, p < 0.001), but negatively correlated with albumin (r = -0.484, p < 0.001). ROC curve analysis indicated that the AUC for miR-7-5p was 0.862, demonstrating high diagnostic value. Furthermore, high miR-7-5p levels were linked to poorer survival rates and were confirmed as an independent prognostic factor for liver cirrhosis (95% CI 1.442-11.811, p = 0.008).

miR-7-5p not only demonstrated potential value in the diagnosis of liver cirrhosis but also effectively predicted patient prognosis. As a biomarker, miR-7-5p may provide important evidence for early diagnosis and the formulation of individualized care strategies for patients, thereby promoting improvements in clinical nursing practice.