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A common variant in NID1 gene associated with the prognosis of heart failure

Dong Hu, Jing Zhao, Lei Xiao

    Human Heredity
    |August 15, 2025
    PubMed

    Insights

    A common NID1 gene variant, rs3738530, is linked to better heart failure (HF) prognosis. This finding suggests NID1 may be a future therapeutic target for HF patients.

    Area of Science:

    • Cardiology
    • Genetics
    • Molecular Biology

    Background:

    • Previous research indicated NID1's protective role in myocardial infarction.
    • Heart failure (HF) remains a significant global health concern with ongoing research into its genetic underpinnings.
    • Understanding genetic factors influencing HF prognosis is crucial for developing targeted therapies.

    Purpose of the Study:

    • To investigate the association between NID1 gene polymorphisms and the prognosis of heart failure (HF).
    • To identify specific NID1 variants that correlate with HF patient outcomes.
    • To elucidate the functional mechanisms linking NID1 variants to HF progression.

    Main Methods:

    • Genotyping analysis of NID1 variants in a discovery cohort (1000 HF patients) and a replication cohort (2266 HF patients).
    • Functional assays including Western blot, transcription assays, and apoptosis assays to explore NID1's role.
    • Clinical data analysis correlating NID1 genotypes with HF patient characteristics and prognosis.

    Main Results:

    • The synonymous variant rs3738530 in the NID1 gene was significantly associated with improved HF prognosis in both cohorts.
    • rs3738530-T allele carriers showed higher NID1 protein and mRNA levels.
    • Overexpression of NID1 demonstrated protective effects against apoptosis in cardiac cells, and carriers of the rs3738530-AT+TT genotype had better cardiac function (higher ejection fraction, smaller end-diastolic diameter).

    Conclusions:

    • The NID1 gene variant rs3738530 is a significant predictor of heart failure prognosis.
    • NID1 plays a role in cardiac cell survival and function, potentially through its influence on apoptosis.
    • NID1 represents a potential therapeutic target for improving outcomes in heart failure patients.

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