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Candida parapsilosis Endocarditis of the Native Tricuspid Valve in a Patient Without Common Risk Factors

Genichiro Fujioka1, Jacob A Powell1, Kamran Vora1

  • 1Texas A&M College of Medicine, Bryan, Texas, USA.

JACC. Case Reports
|August 15, 2025
PubMed
Abstract

Insights

This case highlights Candida parapsilosis endocarditis in a patient with sickle cell disease. Early surgical intervention and dual antifungal therapy are crucial for managing this rare, high-mortality infection.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Mycology

Background:

  • Fungal endocarditis is a rare but severe condition, often fatal.
  • Candida parapsilosis is a common non-albicans Candida species causing endocarditis.
  • Risk factors include intravenous drug use, prosthetics, hospitalization, and immunosuppression.

Observation:

  • A 33-year-old male with sickle cell disease and chronic leg wounds presented with persistent candidemia.
  • Tricuspid valve endocarditis caused by Candida parapsilosis was diagnosed.
  • The patient experienced a septic pulmonary embolism, treated with suction thrombectomy.

Findings:

  • This case details the clinical course of tricuspid valve Candida parapsilosis endocarditis.
  • The patient had no typical risk factors for this specific fungal endocarditis.
  • Adverse events included septic pulmonary embolism.

Implications:

  • Dual antifungal therapy may be necessary for refractory Candida endocarditis.
  • Early surgical intervention is vital if medical management fails, especially to prevent embolic complications.
  • This case underscores the importance of considering fungal endocarditis in at-risk populations, even without classic risk factors.
Keywords:
Candida endocarditisCandida parapsilosisendocarditisinfective endocarditisseptic emboli

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