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Updated: Sep 11, 2025

Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine
Published on: February 16, 2018
Alkene Oxyamination: One-Pot Synthesis of Unprotected N-H Amino γ-Lactones
Agustin M Rodriguez Treviño1, Young-Do Kwon1, László Kürti1
1Department of Chemistry, Rice University, Houston, Texas 77030, United States.
Abstract:
We report a mild, Rh-catalyzed alkene oxyamination protocol for the synthesis of N-H unprotected amino γ-lactones. This method enables efficient coupling of a broad range of alkenyl carboxylic acids (16 examples) with structurally complex, O-activated hydroxylamines (9 examples). The utility of the transformation is further demonstrated through the late-stage functionalization of active pharmaceutical ingredients (3 examples). This operationally simple, one-pot process proceeds via sequential intermolecular, stereospecific olefin aziridination followed by intramolecular aziridine ring-opening.
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