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Sedentary Time and Breast Cancer Risk in the Sister Study Cohort.

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Increased sedentary time is linked to higher breast cancer risk, particularly in postmenopausal women. However, it showed a protective effect in premenopausal women, highlighting the role of menopausal status in this association.

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Area of Science:

  • Epidemiology
  • Oncology
  • Public Health

Background:

  • Previous studies on sedentary behavior and breast cancer (BC) risk have yielded inconsistent findings.
  • Investigating the relationship between sedentary time and BC incidence is crucial for understanding cancer etiology.

Purpose of the Study:

  • To examine the association between sedentary time and breast cancer incidence.
  • To explore how this association differs based on menopausal status over time.

Main Methods:

  • The Sister Study cohort included 50,884 women aged 35-74 with a family history of BC.
  • Sedentary time was assessed via self-report and categorized (≤5, 6-9, ≥10 hours/day).
  • Multivariable Cox regression models analyzed BC incidence, adjusting for covariates and menopausal status.

Main Results:

  • Higher sedentary time (6-9 and ≥10 hours/day) was associated with increased overall BC incidence.
  • The association between sedentary time and BC risk was modified by menopausal status (p-heterogeneity=0.002).
  • Sedentary time showed an inverse association with BC in premenopausal women but a positive association in postmenopausal women.

Conclusions:

  • Increased sedentary time is associated with breast cancer incidence.
  • The direction of the association between sedentary time and breast cancer risk is dependent on menopausal status.