Related Experiment Video
Updated: Sep 11, 2025

Reliably Engineering and Controlling Stable Optogenetic Gene Circuits in Mammalian Cells
Published on: July 6, 2021
Improving long-term stability of optoelectronic oscillators using genetic algorithm-optimized dual-parameter control
Abstract:
We demonstrate a dual-parameter control strategy that simultaneously modulates laser temperature and current to enhance the long-term frequency stability of optoelectronic oscillators (OEOs). A simulation environment was developed to model the frequency control dynamics, within which proportional-integral-derivative (PID) parameters were optimized using a genetic algorithm before hardware development. Experimental results show that the proposed approach expands the effective compensation range to 2.8 K without upgrading hardware, reduces frequency drift to 7.7×10-3 ppm/K, corresponding to the ppb/K level, and achieves an overlapping Allan deviation of 3.2×10-12 at 1000 s, while preserving phase noise performance. Strong agreement between simulated and experimental results (R2=0.998) confirms the effectiveness of the method for robust OEO stabilization.
Related Concept Videos
Time-Domain Interpretation of PD Control
Consider the example of control of motor torque. Initially, a positive...
Time and frequency -Domain Interpretation of Phase-lead Control
The design of phase-lead control involves the strategic placement of poles and zeros to balance steady-state error and system...
Control Systems
At the heart...
Load-frequency control
Combinatorial Gene Control
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...
Time and frequency -Domain Interpretation of Phase-lag Control
Phase-lag controllers do not place a pole at zero, but instead influence the steady-state error by amplifying any...

