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Updated: Sep 11, 2025

Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells
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Published on: February 8, 2018

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A multidimensional analysis and future perspectives of cellular cancer vaccines

Xiao Li1, Ruiyun Song1, Junsong Zhu1

  • 1State Key Laboratory of Targeting Oncology, National Center for International Research of Bio-targeting Theranostics, Guangxi Key Laboratory of Bio-targeting Theranostics, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, Guangxi Talent Highland of Major New Drugs Innovation and Development, Guangxi Medical University, Nanning, Guangxi, 530021, China.

Biochemical and Biophysical Research Communications
|August 15, 2025
PubMed

Insights

Cell-based cancer vaccines harness the immune system to target tumors by enhancing antigen recognition. This review covers diverse platforms, their mechanisms, combinations, and clinical progress in cancer immunotherapy.

Area of Science:

  • Immunology
  • Oncology
  • Biotechnology

Background:

  • Cell-based cancer vaccines are an emerging immunotherapeutic approach.
  • They aim to enhance the immune system's ability to recognize and eliminate cancer cells.
  • Current strategies utilize various cell types like tumor cells and dendritic cells (DCs).

Purpose of the Study:

  • To review different cell-based cancer vaccine platforms.
  • To explain their mechanisms in modulating antitumor immunity.
  • To discuss combinatorial strategies and clinical advancements.

Main Methods:

  • Literature review of preclinical and clinical studies.
  • Analysis of cell-based vaccine platforms and their antigen-presenting capabilities.
  • Exploration of immunomodulatory mechanisms and combination therapies.

Main Results:

  • Preclinical and early-phase clinical trials show promising immunogenicity and clinical responses.
  • Various cell types (autologous/allogeneic tumor cells, DCs, hybrids) are used as vaccine vehicles.
  • Translational challenges remain despite demonstrated potential.

Conclusions:

  • Cell-based cancer vaccines offer a promising strategy for cancer immunotherapy.
  • Understanding their mechanisms and optimizing combinations is crucial for clinical success.
  • Continued research and clinical trials are advancing this field.
Keywords:
Dendritic cellsFusion cellsTumour cellsTumour therapyVaccines

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