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Implication of epigenetic factors in development and recurrence of psoriasis
Jingyi Tang1, Erle Dang1, Gang Wang1
1Department of Dermatology, Xijing Hospital Fourth Military Medical University, Xi'an 710032, PR China.
Abstract:
Psoriasis is a chronic autoimmune skin disease characterized by abnormal proliferation and differentiation of keratinocytes, with a complex pathogenesis often linked to environmental and genetic factors. Although many treatments are available, the disease still exhibits a high recurrence rate. Epigenetic regulation appears to bridge external stimuli and genetic abnormalities in the development of psoriasis. Skin-resident cells may contribute to disease recurrence through an 'inflammatory memory' formed through epigenetic modifications. This review focuses on skin-resident cells in psoriasis, elucidating their roles in disease progression and recurrence from an epigenetic perspective, providing scientific evidence for targeted therapies.
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