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DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications
Published on: September 27, 2019
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DNA nanostructures: From molecular folding assembly to target subcellular delivery
Danqing Yu1, Liumei Zhong1, Bing Liu2
1Department of Endocrinology, Fifth Affiliated Hospital of Wenzhou Medical University, Lishui 323000, China.
Colloids and Surfaces. B, Biointerfaces
|August 15, 2025
Summary
DNA nanostructures offer precise subcellular delivery of functional molecules for enhanced diagnostics and therapeutics. This review guides the construction of DNA-based targeted delivery systems at the cellular level.
Area of Science:
- Biotechnology
- Nanotechnology
- Molecular Biology
Background:
- Subcellular organelle structure and composition are critical indicators of cellular and organismal health.
- Targeted delivery of functional molecules to specific subcellular locations is essential for advanced diagnostics and therapeutics.
Purpose of the Study:
- To review the development of DNA functional elements and nanotechnology.
- To focus on the subcellular localization of DNA nanoarchitectures and their applications.
- To discuss limitations and future prospects of DNA nanostructures in targeted delivery.
Main Methods:
- Review of existing literature on DNA functional elements and nanotechnology.
- Analysis of studies focusing on subcellular localization of DNA nanoarchitectures.
- Examination of applications in biological detection, bioimaging, and therapeutics.
Main Results:
- DNA nanostructures offer biocompatibility, programmability, and addressability for integrating targeting molecules, sensors, and drugs.
- DNA nanoarchitectures demonstrate advancements in biological detection, bioimaging, and therapeutic applications.
- Current limitations in targeted delivery for DNA nanostructures were identified.
Conclusions:
- DNA nanostructures provide a versatile platform for precise subcellular targeting.
- Further development is needed to overcome limitations in DNA nanostructure-based targeted delivery.
- This review offers a guideline for creating DNA-based targeted delivery systems at the subcellular level.
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