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Related Concept Videos

Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

52
Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
52
Aortic Regurgitation I: Introduction01:15

Aortic Regurgitation I: Introduction

36
IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
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Aortic Regurgitation III: Medical Management01:25

Aortic Regurgitation III: Medical Management

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Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...
43
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

23
Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
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Long-Term Impact of Prosthesis-Patient Mismatch After Transcatheter Aortic Valve Replacement in Patients With Small Aortic Annuli.

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Related Experiment Video

Updated: Sep 11, 2025

Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots
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Published on: May 21, 2017

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Transcatheter Aortic Valve Replacement Wait-list Failure-Correlation With Cardiac Damage Stage.

Itamar Loewenstein1, Aviram Hochstadt2, Tami Jacoby1

  • 1Cardiology Department, Tel-Aviv Sourasky Medical Center, Affiliated to The Faculty of Medical and Health Sciences, Tel-Aviv University, Tel-Aviv, Israel.

The Canadian Journal of Cardiology
|August 15, 2025
PubMed
Summary
This summary is machine-generated.

Cardiac damage staging predicts adverse events in patients awaiting Transcatheter aortic valve replacement (TAVR). Advanced stages indicate higher risk of hospitalization and mortality, aiding TAVR candidate prioritization.

Keywords:
Transcatheter aortic valve replacementcardiac damage stagehospitalizationprioritizationwait-list failurewaiting time

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Area of Science:

  • Cardiology
  • Echocardiography
  • Interventional Cardiology

Background:

  • Growing waitlists for Transcatheter aortic valve replacement (TAVR) highlight the need for effective candidate prioritization.
  • Aortic stenosis (AS)-related cardiac damage (CD) staging offers a framework to assess structural damage in AS patients.
  • Adverse events can occur while patients await TAVR, emphasizing the urgency for improved risk stratification.

Purpose of the Study:

  • To evaluate the correlation between cardiac damage (CD) staging and AS-related adverse events in patients awaiting TAVR.
  • To determine if CD staging can predict waitlist failure (WF) in this patient population.

Main Methods:

  • A cohort of 904 patients with symptomatic severe AS undergoing TAVR evaluation between 2018-2022 was analyzed.
  • Waitlist failure (WF), defined as AS-related hospitalizations or mortality, was the primary outcome.
  • Multivariable logistic regression identified predictors of WF, including CD staging, frailty, and hypoalbuminemia.

Main Results:

  • Waitlist failure (WF) occurred in 8.0% of patients.
  • Higher CD stages on echocardiography correlated with an increased risk of WF.
  • CD staging was an independent predictor of WF (continuous: HR 1.66; categorical stage ≥3: HR 2.24), alongside frailty and hypoalbuminemia.

Conclusions:

  • Advanced cardiac damage (CD) stage is a significant independent predictor of adverse events, including hospitalization and mortality, in patients awaiting TAVR.
  • CD staging provides valuable information for prioritizing TAVR candidates and managing waitlist risks.
  • Integrating CD staging into clinical practice can help optimize TAVR candidate selection and improve patient outcomes.