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Updated: Sep 11, 2025
06:22
Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome ARDS
Published on: April 7, 2021
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Pulmonary surfactant in asthma
Odalys Blanco1, Mercyleidi Díaz-Reyes1, Alexis Labrada2
1Grupo de Investigación Farmacéutica, Centro Nacional de Sanidad Agropecuaria (CENSA), San José de las Lajas, CP 32 700, Mayabeque, Cuba.
European Journal of Pharmacology
|August 15, 2025
Summary
Pulmonary surfactant is crucial for respiration and asthma management. Dysfunction contributes to airway constriction, but therapeutic surfactant may offer benefits by restoring function and modulating immune responses in asthma patients.
Area of Science:
- Pulmonary medicine
- Respiratory physiology
- Immunology
Background:
- Pulmonary surfactant maintains alveolar stability and airway patency, crucial for efficient gas exchange.
- Surfactant dysfunction is linked to severe lung disorders and plays a role in asthma pathogenesis and exacerbation.
- The surfactant system influences both innate and adaptive immune responses, impacting asthma susceptibility and resolution.
Purpose of the Study:
- To review and synthesize current knowledge on the relationship between pulmonary surfactant and asthma.
- To elucidate the role of pulmonary surfactant in asthma mechanisms and manifestations.
- To explore the potential of exogenous surfactant as a therapeutic strategy for asthma.
Main Methods:
- Literature review of experimental evidence and clinical trials.
- Analysis of the mechanisms underlying surfactant's role in airway dynamics and immune modulation.
- Synthesis of data on exogenous surfactant administration in asthma.
Main Results:
- Surfactant dysfunction contributes to airway constriction and asthma exacerbation.
- Exogenous surfactant may offer therapeutic benefits in asthma by restoring surface activity and modulating immune responses.
- Evidence suggests a dual role for surfactant in asthma: contributing to pathology and offering therapeutic potential.
Conclusions:
- Pulmonary surfactant is integral to respiratory health and significantly impacts asthma.
- Targeting the surfactant system presents a promising avenue for novel asthma therapies.
- Further research is warranted to optimize exogenous surfactant administration for asthma management.
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