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Author Spotlight: Shear Assay Protocol for the Determination of Single-Cell Material Properties
Published on: May 19, 2023
Mechanical stress and mechanosensitive protein in skin tumors
Baixin Li1, Shuang Zhao1, Lingling Zhang1
1Department of Dermatology, Xiangya Hospital, Central South University, Changsha 410008, China; Furong Laboratory (Precision Medicine), Changsha 410008, China; National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Xiangya Hospital, Central South University, Changsha 410008, China; Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Central South University, Changsha 410008, China; Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South University, Changsha 410008, China; National Clinical Research Center of Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, China.
Abstract:
The skin is highly susceptible to external physical stimuli, and mechanical stresses contribute to certain skin tumors. Focusing on keloid, basal cell carcinoma, cutaneous squamous cell carcinoma and melanoma, we systematically examined the roles and mechanisms between mechanical stresses, such as tensile stress and matrix stiffness, and mechanosensitive proteins, including Piezo, transient receptor potential (TRP), integrin family, Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ), in skin tumor progression. Additionally, we analyze existing research challenges and bottlenecks in this field. This review aims to further deepen the knowledge of skin tumorigenesis from the perspective of mechanical stress, which may help identify diagnostic and prognostic biomarkers and develop novel therapies, ultimately optimizing clinical management of skin tumors.
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