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Updated: Sep 11, 2025
Visualization and Analysis of Blood Flow and Oxygen Consumption in Hepatic Microcirculation: Application to an Acute Hepatitis Model
Published on: August 4, 2012
Portal hypertension in alcohol-associated hepatitis: harmless and the reflection of systemic inflammation?
Karim Gebara1, Lionel Moulis2, Joana Pissarra2
1Department of Hepato-gastroenterology, Hepatology and Liver Transplantation Unit, Saint Eloi Hospital, Univ Montpellier, Montpellier, France.
Background And Aims:
Portal hypertension is a prominent feature of alcohol-associated hepatitis. However, it is not established whether the severity of PH has a prognostic impact in AH. The aim of our study was to assess the impact of PH on 6-month transplantation-free survival (TFS).
Methods:
A monocentric retrospective analysis was conducted on patients with symptomatic AH, proven histologically, admitted in our tertiary care hospital from January 2013 to December 2021.
Results:
127 patients were included in the study, with a mean Discriminant Function and MELD score of 59.5 (±23.5) and 25.2 (±6.6), respectively. The only risk factor for severe PH at admission was the liver/spleen ratio. Patients were followed up for a median of 20 months. The median TFS was 16.8 months. Severe PH was not significantly associated with 6-month TFS, unlike the MELD score and nonresponse to corticosteroids. In addition, the leucocyte count was associated with persistent PH at 6 months.
Conclusions:
In our study, severe PH had no impact on 6-month TFS. Further investigations on the prognostic value of PH and its natural history in AH are warranted.
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