Neuroprotective mechanism of LincRNA in neurodegenerative diseases

Neurodegenerative diseases (NDs), such as Alzheimer's disease, Parkinson's disease , and Huntington's disease, are characterized by progressive neuronal dysfunction and cell death associated with protein aggregation, mitochondrial dysfunction, and neuroinflammation. Since the precise pathogenesis of NDs remains unclear, current therapeutic options are limited to symptomatic relief with minimal disease-modifying effects. Emerging evidences highlight the critical regulatory roles of long non-coding RNAs (lncRNAs) in the onset and progression of NDs through epigenetic modulation, mRNA stability control, and protein scaffolding. Among these, long intergenic non-coding RNAs (lincRNAs) have attracted significant attention for their dual roles in neuroprotection and neurodegeneration. These lincRNAs modulate disease-related genes through chromatin remodeling, miRNA sponging, and stress granule formation. This review systematically analyzes lincRNA expression signatures across NDs, their mechanistic roles in protein homeostasis, and emerging therapeutic strategies including antisense oligonucleotides and CRISPR-based approaches.