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Desmoplakin Cardiomyopathy Presenting With Recurrent Myopericarditis Responsive to Interleukin-1 Blockade

Rocio I Lopez1, Michele Marchetta1, Michael Ayers1

  • 1Department of Medicine, Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, Virginia, USA.

JACC. Case Reports
|August 15, 2025
PubMed
Summary

Recurrent myopericarditis linked to desmoplakin (DSP) variants may benefit from interleukin-1 blockade. Rilonacept effectively reduced symptoms and medication dependence in a patient with DSP variants.

Keywords:
desmoplakininterleukin-1myopericarditis

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