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[Mefenamic acid (Ponstan)-induced acute interstitial nephritis with reversible, severe, non-oliguric renal failure]
Schweizerische Medizinische Wochenschrift
|November 30, 1985
Abstract:
Acute interstitial nephritis is a rare complication of treatment with non-steroidal antiinflammatory drugs. A case is reported with severe, reversible, non-oliguric renal failure caused by biopsy-proven acute interstitial nephritis after therapy with mefenamic acid (Ponstan). Prednisone treatment resulted in normalization of renal function within 4 weeks.
Insights
Non-steroidal anti-inflammatory drugs can cause acute interstitial nephritis. This case shows severe kidney injury from mefenamic acid, which resolved with prednisone treatment.
Area of Science:
- Nephrology
- Pharmacology
Background:
- Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used for pain and inflammation.
- Acute interstitial nephritis (AIN) is a rare but serious adverse reaction to certain medications, including NSAIDs.
Observation:
- A patient developed severe, non-oliguric renal failure.
- Kidney biopsy confirmed acute interstitial nephritis attributed to mefenamic acid therapy.
Findings:
- Mefenamic acid, an NSAID, triggered biopsy-proven acute interstitial nephritis.
- Renal function significantly improved and normalized within four weeks of initiating prednisone treatment.
Implications:
- Early recognition and treatment of NSAID-induced AIN are crucial for renal recovery.
- Corticosteroid therapy, such as prednisone, is effective in managing NSAID-induced acute interstitial nephritis.
- This case highlights the importance of considering drug-induced nephrotoxicity in patients presenting with acute kidney injury.