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Related Concept Videos

Naturalistic Observations02:30

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Related Experiment Video

Updated: Jun 23, 2026

Mobile Game-based Virtual Reality Program for Upper Extremity Stroke Rehabilitation
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Virtual Reality as RESPITE: Relief Exploration for Sickle Pain Through Interventions Using Technology Engagement: A

Nitin Vidyasagar1, May Nguyen2, Andrea Bundy3

  • 1Pritzker School of Medicine, The University of Chicago, Chicago, USA.

Journal of General Internal Medicine
|August 15, 2025
PubMed
Summary

Most adults with sickle cell disease (SCD) are interested in using virtual reality (VR) for pain management. Low health literacy and electronic health literacy were barriers for those uninterested in VR.

Keywords:
electronic health literacyhealth literacypainsickle cellvirtual reality

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Area of Science:

  • Pain management interventions
  • Digital health technologies
  • Sickle cell disease (SCD) research

Background:

  • Opioid use and side effects necessitate novel pain management strategies for sickle cell disease (SCD).
  • Virtual reality (VR) shows promise for pediatric SCD patients, but adult interest is understudied.
  • Understanding patient interest is crucial for equitable access to VR interventions.

Purpose of the Study:

  • Assess adult interest in VR for SCD pain management.
  • Identify preferences and predictors of VR interest.
  • Examine the role of health literacy in VR adoption.

Main Methods:

  • Cross-sectional, observational study of 40 hospitalized adults with SCD.
  • Assessed interest in VR for pain management.
  • Measured general health literacy (HL) and electronic health literacy (eHL).

Main Results:

  • 85% of participants expressed interest in using VR for pain management.
  • Low HL and eHL were significantly associated with lower interest in VR.
  • Preferred VR genres included skill development and adventure; cost and device access were key barriers.

Conclusions:

  • Adults with SCD view VR as a promising pain management tool.
  • Future VR interventions must address health literacy and accessibility.
  • Further research should focus on efficacy and equitable design of VR for SCD.