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Updated: Sep 11, 2025

In vitro Organoid Culture of Primary Mouse Colon Tumors
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ARHGAP4/MYH9/β-catenin/c-Jun positive feedback loop promotes colorectal cancer stemness

Shaolin Liu1,2, Yizhen Chen1,2, Song Tan1,2

  • 1Shengli Clinical Medical College of Fujian Medical University, Fuzhou, China.

NPJ Precision Oncology
|August 16, 2025
PubMed
Summary

Rho GTPase-activating protein 4 (ARHGAP4) drives colorectal cancer stemness via a MYH9/β-catenin/c-Jun feedback loop. This discovery highlights ARHGAP4 as a potential therapeutic target for colorectal cancer stem cells.

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