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Functionalized Mildly Oxidized MXene-Based Injectable Hydrogel with Enhanced Photothermal Performance for Precision
Jinfeng Yan1,2,3,4,5, Xiaofan Gao1,2,3, Qianyi Ma1,2,3
1National Clinical Research Center for Obstetrical and Gynecological Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430074, China.
Abstract:
Uterine sarcoma is an extremely malignant gynecological tumor, characterized by rapid growth, early metastasis, and a high recurrence rate. Current treatments like surgery, radiotherapy, and chemotherapy, have limited effectiveness, highlighting the urgent need for innovative noninvasive alternatives. Here, we report a novel photosensitive nanocomposite hydrogel (O1-M&F) designed for NIR-induced photothermal therapy (PTT), comprising mildly oxidized MXene (O1-M) and a thermosensitive Pluronic F127 hydrogel. Unlike conventional approaches that aim to prevent MXene oxidation, we demonstrate that mild oxidation significantly enhances both the photothermal conversion efficiency and reactive oxygen species (ROS) generation of MXene nanosheets. The incorporation of F127 hydrogel further ensures the long-term dispersion stability and biocompatibility of the composite system. In vitro and in vivo studies demonstrated potent tumor ablation capability with minimal side effects. Increased apoptosis of uterine sarcoma cells was further observed. The biocompatibility of the O1-M&F hydrogel was validated, indicating its potential for safe and effective therapeutic application. These findings suggest that O1-M&F-based PTT is a promising, noninvasive, effective treatment for uterine sarcoma, offering a novel therapeutic approach with reduced risks and enhanced patient outcomes.
Insights
A new photosensitive hydrogel (O1-M&F) effectively treats uterine sarcoma using near-infrared light. This noninvasive photothermal therapy (PTT) shows potent tumor ablation with minimal side effects, offering a promising alternative cancer treatment.
Area of Science:
- Biomedical Engineering
- Materials Science
- Oncology
Background:
- Uterine sarcoma is a highly malignant gynecological tumor with poor treatment outcomes.
- Current therapies (surgery, radiotherapy, chemotherapy) have limited efficacy and significant side effects.
- There is an urgent need for innovative, noninvasive treatment strategies for uterine sarcoma.
Purpose of the Study:
- To develop and evaluate a novel photosensitive nanocomposite hydrogel (O1-M&F) for near-infrared (NIR)-induced photothermal therapy (PTT).
- To investigate the enhanced photothermal and reactive oxygen species (ROS) generation properties of mildly oxidized MXene (O1-M).
- To assess the efficacy and biocompatibility of the O1-M&F hydrogel for uterine sarcoma treatment.
Main Methods:
- Fabrication of a nanocomposite hydrogel (O1-M&F) using mildly oxidized MXene (O1-M) and Pluronic F127 hydrogel.
- Characterization of O1-M&F for photothermal conversion efficiency, ROS generation, dispersion stability, and biocompatibility.
- In vitro and in vivo evaluation of O1-M&F-based PTT for uterine sarcoma tumor ablation.
Main Results:
- Mild oxidation of MXene significantly enhanced photothermal conversion efficiency and ROS generation.
- The O1-M&F hydrogel demonstrated excellent dispersion stability and biocompatibility.
- Effective in vitro and in vivo uterine sarcoma tumor ablation with minimal observed side effects.
- Increased apoptosis in uterine sarcoma cells was confirmed.
Conclusions:
- O1-M&F nanocomposite hydrogel is a safe and effective platform for NIR-induced PTT.
- This novel PTT approach shows significant potential for noninvasive uterine sarcoma treatment.
- The O1-M&F hydrogel offers a promising therapeutic strategy with reduced risks and improved patient outcomes.
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