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Centrosome-Signaling Pathway Crosstalk: A Core Hub From Cellular Homeostasis to Disease
Mingyu Pan1, Jinghan Li1, Jingyan Fu1
1State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China.
Abstract:
The centrosome, an evolutionarily conserved organelle in most animal cells, plays a pivotal role in fundamental processes such as cell division and ciliogenesis. Recent evidence increasingly highlights active crosstalk between the centrosome and the signaling pathways, through which cells dynamically detect and respond to diverse extracellular and intracellular cues. In this review, we summarize the roles of the centrosome in multiple signaling pathways, including Hedgehog, Wnt, and Notch that govern cellular growth, division, differentiation, and tissue homeostasis. We also explore how these interactions mold centrosomal behavior, emphasizing its function as a hub for signaling integration.
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