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Updated: May 4, 2026
Imaging CD4 T Cell Interstitial Migration in the Inflamed Dermis
Published on: March 25, 2016
Anterior scleritis with IgG4 lymphoplasmacytic infiltration: a case report
Poojitha Balakrishnan1, Matthew G Vicinanzo2,3, John P Luckett2
1Department of Ophthalmology and Visual Sciences, University of Alabama School of Medicine, 1720 University Boulevard, Suite 302, Birmingham, AL, 35233, USA. pbalakr2@jh.edu.
Purpose:
To report a case of chronic unilateral nodular anterior scleritis as a rare, isolated presentation of IgG4-related ophthalmic disease.
Case:
A fifty-two-year-old patient was evaluated for painful, nodular scleral injection of the right eye, diagnosed as nodular anterior scleritis. There was only a partial response to topical corticosteroid and systemic immunomodulatory therapy. This, in combination with a sharp delineation between normal and abnormal sclera lead to the decision to perform a diagnostic biopsy of the lesion. Histopathology showed an IgG4 lymphoplasmacytic infiltration of the scleral tissue.
Conclusions:
There are few documented reports of scleritis as the presenting manifestation of IgG4-related disease. IgG4-related disease is an increasingly recognized etiology to be considered in evaluating and managing scleritis.
