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Related Concept Videos

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Regeneration is the process of restoring injured or lost tissues, organs, or body parts. While simpler organisms generally show greater ability to regenerate their whole body, few complex animals show similarly exceptional regeneration. For example, planarian flatworms have a unique regenerative potential making them a popular study organism among biologists to understand the mechanisms of whole body regeneration. Other organisms, such as hydra, also show extreme regeneration potential;...
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Updated: Sep 11, 2025

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Tooth regeneration in animals. A systematic review.

J Bartolomé-Lechuga1, L Hernando-Calzado, C-M Cobo-Vázquez

  • 1Department of Clinical Specialities Faculty of Dentistry. Complutense University of Madrid Plaza Ramón y Cajal, 3. 28040 Madrid, Spain cmcobo@ucm.es.

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Dental regeneration research advances understanding of molecular signaling pathways for bioengineered teeth. Key genes like Wnt10a and Bmp6 are identified, but complete tooth regeneration requires further study of cellular sources and genetic factors.

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Area of Science:

  • Regenerative Medicine
  • Developmental Biology
  • Oral Biology

Background:

  • Understanding molecular signaling networks is crucial for bioengineered tooth replacement.
  • Organoid research, including dental organoids, is a growing area in craniofacial development.
  • Spheroid cultures are being explored for their potential in regenerative applications.

Purpose of the Study:

  • To provide a comprehensive overview of current knowledge on dental regeneration.
  • To synthesize findings on molecular mechanisms and genetic factors in dental development and regeneration.
  • To identify gaps and future directions in complete tooth regeneration.

Main Methods:

  • Systematic review registered in PROSPERO (CRD 646053) following PRISMA guidelines.
  • PICO question: "In animals (P) subjected to bioengineering techniques (I), is successful dental regeneration achieved (O)?"
  • Risk of bias assessment using Arrive and JBI adapted for Quasi-experimental studies tools.

Main Results:

  • 83 articles published in the last 5 years were reviewed; 4 met the inclusion criteria.
  • Complete dental regeneration in animal models was achieved by stimulating genes like Wnt10a, Bmp6, and Grem2a.
  • Identified genes and antibodies influencing BMP and Wnt signaling pathways (Sox-2), and key factors like FGF.

Conclusions:

  • Significant advancements in understanding signaling pathways for dental formation exist, but complete tooth regeneration remains challenging.
  • Progress in animal models and genetic editing is noted, yet identifying optimal cellular sources is essential.
  • Further research into key genes and cellular sources is critical for future clinical applications in dental regeneration.