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Live Cell Imaging of Chromosome Segregation During Mitosis

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Jenn-Jhy Tseng¹, Chien-Hsing Lu², Li-Yuan Huang³

¹Department of Obstetrics and Gynecology, Taichung Veterans General Hospital, Taichung, 402, Taiwan; Department of Nursing, College of Nursing, HungKuang University, Taichung, Taiwan.

Computers in Biology and Medicine

|August 16, 2025

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This summary is machine-generated.

A new deep learning model, MCSegNet, automates chromosome segmentation for prenatal diagnosis. This AI tool significantly improves accuracy and efficiency in analyzing fetal chromosomes, aiding early detection of genetic disorders.

Area of Science:

Genetics
Medical Imaging
Artificial Intelligence

Background:

Chromosome abnormalities are linked to genetic disorders, necessitating prenatal screening.
Manual chromosome analysis is time-consuming and error-prone, especially with overlapping chromosomes in images.
Existing karyotype analysis systems struggle with accurate chromosome detection, segmentation, and orientation.

Purpose of the Study:

To develop an automated deep learning model for precise chromosome segmentation.
To overcome the limitations of manual analysis in prenatal diagnosis.
To improve the accuracy and efficiency of karyotype analysis.

Main Methods:

Developed MCSegNet, a three-stage deep learning model.
Utilized Swin Transformer for feature extraction.

Keywords:

Chromosome screening Deep learning Diagnostic assistance system Segmentation

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Employed Hybrid Task Cascade and test-time augmentation for robust detection and segmentation.

Main Results:

Achieved 98.9% accuracy and precision.
Reached 99.7% recall and 99.3% Dice coefficient on a dataset of 30,055 images.
Demonstrated superior performance compared to existing methods.

Conclusions:

MCSegNet is practical and robust for clinical applications.
The model enhances accuracy and efficiency in prenatal diagnosis.
It reduces the workload for medical professionals in laboratory settings.