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Related Experiment Video

Updated: Sep 11, 2025

A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells
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A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells

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Empowering single-cell analysis with emerging active microfluidic devices.

Qingyu Ruan1, Wenshang Guo1, Ruizhe Yang1

  • 1State Key Laboratory of Robotics and System, School of Mechatronics Engineering, Harbin Institute of Technology, Harbin, 150001, PR China.

Biomaterials
|August 16, 2025
PubMed
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Active microfluidics enhances single-cell analysis by integrating multiple technologies for precise, non-invasive isolation and real-time study. This review explores advances, applications, and challenges in active microfluidic systems for biomedical research.

Area of Science:

  • Biomedical Engineering
  • Cell Biology
  • Analytical Chemistry

Background:

  • Cellular heterogeneity is key to understanding diseases and developing personalized therapies.
  • Microfluidics offers efficient single-cell analysis but has limitations like off-chip processing and cell damage.
  • Active microfluidics integrates technologies to overcome these limitations.

Purpose of the Study:

  • To review recent advancements in active microfluidics for single-cell analysis.
  • To discuss applications in nucleic acid, protein, cellular, and omic analyses.
  • To provide guidance on selecting appropriate methods and identify future research directions.

Main Methods:

  • Review of current literature on active microfluidic technologies.
  • Analysis of integrated electrical, magnetic, acoustic, and optical techniques.
Keywords:
Active microfluidicsDielectrophoresisDigital microfluidicsLab-on-a-chipSingle cells

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Last Updated: Sep 11, 2025

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A Microfluidic Platform for High-throughput Single-cell Isolation and Culture
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  • Evaluation of single-cell isolation, manipulation, and analysis capabilities.

    • Main Results:

    • Active microfluidics enables precise, non-invasive, and high-throughput single-cell analysis.
    • Applications span diverse fields including omics, protein, and nucleic acid studies.
    • Identified pros and cons of various active microfluidic approaches.

    Conclusions:

    • Active microfluidics represents a significant improvement over traditional microfluidic methods for single-cell analysis.
    • Further development is needed to address current workflow limitations.
    • This technology holds great promise for advancing biomedical research and diagnostics.