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Regulation of Food Intake01:30

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Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
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Updated: Sep 11, 2025

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Feeding-induced olfactory cortex suppression reduces satiation.

Hung Lo1, Walter Cañedo Riedel2, Malinda L S Tantirigama3

  • 1Charité-Universitätsmedizin Berlin, Neuroscience Research Center, Charitéplatz 1, 10117 Berlin, Germany; Charité-Universitätsmedizin Berlin, Einstein Center for Neurosciences Berlin, Charitéplatz 1, 10117 Berlin, Germany; Charité-Universitätsmedizin Berlin, Institute of Cell and Neurobiology, 10117 Berlin, Germany.

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PubMed
Summary
This summary is machine-generated.

Binge eating suppresses brain responses to food flavor, reducing satiation. This brain activity change, linked to motivation, drives overeating during binges.

Keywords:
Ca(2+) imagingbinge eatingconsumptionflavorfunctional connectivityolfactory tubercleoptogeneticspiriform cortexsensory satiationsmell

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Area of Science:

  • Neuroscience
  • Sensory processing
  • Feeding behavior

Background:

  • Flavor perception is crucial for satiation.
  • Binge feeding often leads to overeating.
  • Neural mechanisms linking flavor, binge feeding, and intake are unclear.

Purpose of the Study:

  • Investigate neural responses in the anterior piriform cortex (aPC) during feeding.
  • Determine how binge feeding alters flavor processing and satiation.
  • Elucidate the role of the olfactory tubercle (OT) in regulating feeding behavior.

Main Methods:

  • In vivo calcium imaging using miniscopes in freely moving mice.
  • Recording neuronal activity in the aPC during slow and binge feeding.
  • Optogenetic manipulation of neuronal circuits.
  • Analysis of neuronal responses to food flavors and value.

Main Results:

  • Specific neuronal responses to flavors during slow feeding became globally suppressed during binge feeding.
  • aPC suppression intensity correlated with the food's value.
  • GABAergic neurons in the OT projected to the aPC, mirroring its activity.
  • Suppressing aPC activity during binge feeding reduced satiation and prolonged feeding bouts.

Conclusions:

  • Olfactory tubercle suppresses anterior piriform cortex activity during binge feeding.
  • This suppression reduces sensory satiation, promoting increased food intake.
  • The findings reveal a neural mechanism underlying overeating in binge states.