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Merkel Cell Carcinoma: A Rare and Underdiagnosed Entity.

Ronen Toledano1, Adi Maisel Lotan1, Hadas Yarimi2

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Merkel cell carcinoma (MCC) is a rare skin cancer. This study highlights unique patient characteristics and an 82% 2-year survival rate, emphasizing early detection for better outcomes.

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Area of Science:

  • Oncology
  • Dermatology
  • Epidemiology

Background:

  • Merkel cell carcinoma (MCC) is a rare, aggressive neuroendocrine skin tumor with rising incidence.
  • MCC predominantly affects older individuals, accounting for less than 1% of skin malignancies.

Purpose of the Study:

  • To characterize clinical presentation, treatments, and outcomes for MCC patients.
  • To increase clinical awareness for early MCC recognition and diagnosis.

Main Methods:

  • Retrospective cohort study of 17 MCC patients at Shaare Zedek Medical Center (2015-2022).
  • Analysis of demographic, epidemiological, clinical, and pathological data.

Main Results:

  • The cohort (mean age 70.06) showed predominantly female patients and Jewish origin.
  • Common comorbidities included hypertension (64.7%) and diabetes (35.3%).
  • 29.4% had lymph node involvement, and 23.5% presented with metastatic disease; ischemic heart disease correlated with lower survival (P=0.009).

Conclusions:

  • The study identified unique MCC characteristics, including female predominance and a slightly younger average age at diagnosis.
  • The 2-year survival rate was 82%, underscoring the critical role of early detection and diagnosis in improving patient outcomes.