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Related Experiment Videos

IgD multiple myeloma. A case report.

J Dauth, W M Politzer, A G Christodoulou

    South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde
    |December 21, 1985
    PubMed
    Summary

    A patient with a femur fracture was diagnosed with IgD myeloma, a rare cancer. Initial tests for multiple myeloma were normal, but Bence Jones proteinuria indicated the correct diagnosis.

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    Area of Science:

    • Hematology
    • Oncology
    • Clinical Diagnostics

    Background:

    • Multiple myeloma is a cancer of plasma cells, often presenting with bone lesions.
    • Diagnostic workup typically involves serum protein electrophoresis and immunoglobulin quantification.

    Observation:

    • A patient presented with a left femur fracture, prompting investigation for multiple myeloma.
    • Initial laboratory results, including serum total proteins and immunoglobulins G, A, and M, were unremarkable.

    Findings:

    • Despite normal initial findings, Bence Jones proteinuria of the lambda type was detected.
    • Further investigations confirmed the presence of immunoglobulin D (IgD) myeloma.

    Implications:

    • This case highlights the importance of investigating Bence Jones proteinuria even with normal serum immunoglobulin levels.
    • IgD myeloma is a rare subtype requiring specific diagnostic considerations.
    • Early and accurate diagnosis is crucial for appropriate management of rare plasma cell dyscrasias.

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