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Associations of ANGPTL proteins and complexes with progression of coronary artery calcification and coronary events

  • 0Division of Angiology, Department of Internal Medicine, Medical University of Graz, Graz, Auenbruggerplatz 15, 8036, Graz, Austria.
Atherosclerosis +

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August 17, 2025

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August 17, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

C-terminal domain-containing ANGPTL4 (CD-ANGPTL4) and ANGPTL4/8 levels are linked to coronary artery calcification progression and heart events, unlike ANGPTL3 and ANGPTL3/8.

Area Of Science

  • Cardiovascular Research
  • Biochemistry
  • Proteomics

Background

  • Angiopoietin-like protein 8 (ANGPTL8) interacts with ANGPTL3 and ANGPTL4 to regulate lipoprotein lipase (LPL) activity.
  • Reduced LPL activity is a known cardiovascular risk factor.
  • Serum levels of ANGPTL4/8 and C-terminal domain-containing ANGPTL4 (CD-ANGPTL4) correlate with cardiovascular mortality, but mechanisms are unclear.

Purpose Of The Study

  • To investigate the association of ANGPTL3, ANGPTL3/8, CD-ANGPTL4, and ANGPTL4/8 with coronary artery calcification (CAC) progression.
  • To examine the relationship between these proteins and the incidence of coronary events.

Main Methods

  • Measurements of ANGPTL3, ANGPTL3/8, CD-ANGPTL4, and ANGPTL4/8 were performed using immunoassays.
  • The study cohort comprised 2887 participants from the Heinz Nixdorf Recall (HNR) study, initially free of cardiovascular disease.
  • CAC was assessed at baseline and after 5 years, with coronary events followed for a median of 18.8 years.

Main Results

  • ANGPTL3 and ANGPTL3/8 levels were not associated with Agatston score progression.
  • ANGPTL3 showed an association with incident coronary events, but ANGPTL3/8 did not.
  • CD-ANGPTL4 and ANGPTL4/8 were positively associated with both CAC progression (Agatston score) and incident coronary events.

Conclusions

  • Associations between ANGPTL3/ANGPTL3/8 and coronary atherosclerosis progression/events were inconsistent.
  • CD-ANGPTL4 and ANGPTL4/8 demonstrated clear associations with both coronary atherosclerosis progression and incident coronary events.
  • The link between ANGPTL4/8, CD-ANGPTL4, and cardiovascular events may involve diabetes, inflammation, or intrinsic effects of these proteins.

Keywords:

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