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Accelerated vascular ageing after COVID-19 infection: the CARTESIAN study
Rosa Maria Bruno1,2, Smriti Badhwar1, Leila Abid3
1INSERM U970, Paris Cardiovascular Research Centre-PARCC, Université Paris Cité, 56 Rue Leblanc, Paris 75015, France.
European Heart Journal
|August 17, 2025
Summary
COVID-19 survivors show accelerated vascular aging, particularly women, indicated by increased arterial stiffness. This vascular damage may persist long-term, highlighting the need for cardiovascular monitoring post-infection.
Area of Science:
- Cardiovascular Medicine
- Infectious Diseases
- Vascular Biology
Background:
- COVID-19 survivors may face long-term cardiovascular issues due to vascular damage.
- Accelerated vascular aging is a potential complication following SARS-CoV-2 infection.
Purpose of the Study:
- To investigate if COVID-19 infection leads to accelerated vascular aging.
- To identify factors contributing to vascular aging post-COVID-19.
Main Methods:
- Prospective, multicentric cohort study across 34 centers in 16 countries.
- Included COVID-19-negative controls and three groups of SARS-CoV-2 exposed individuals (non-hospitalized, ward, ICU).
- Carotid-femoral pulse wave velocity (PWV) measured as the primary outcome for arterial stiffness.
Main Results:
- All COVID-19 positive groups exhibited significantly higher PWV compared to controls.
- PWV increase was pronounced in women, with persistent symptoms correlating to higher PWV.
- COVID-19 positive groups showed stable PWV over 12 months, while controls had progression.
Conclusions:
- COVID-19 is linked to long-term, accelerated vascular aging.
- Women appear particularly susceptible to developing vascular aging after COVID-19.
- Persistent symptoms in women are associated with increased arterial stiffness post-COVID-19.
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