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Updated: Sep 11, 2025

Author Spotlight: Decoding Mitochondrial Aging
Published on: June 30, 2023
Mitotherapy Restores mitochondrial function and improves cognitive deficits in Alzheimer's disease
Tulika Gupta1, Asha Rao1, Veena Devi1
1Department of Anatomy, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
None:
Mitochondrial dysfunction is a hallmark of Alzheimer's disease (AD), contributing to cognitive decline. This study explores the therapeutic potential of mitochondrial transplantation in mitigating cognitive decline in AD. Structurally and functionally characterized mitochondria from young rat brains were intravenously transplanted into AD rats. Confocal imaging confirmed integration of exogenous tagged mitochondria into hippocampal tissue. Post-mitotherapy, we noted significant cognitive improvement by neurobehavioral tests and significant reduction in protein levels of amyloid precursor protein. Further mitochondrial functional parameters improved; reduced oxidative stress, improved mitochondrial membrane potential, and calcium homeostasis. These findings highlight mitotherapy as a promising strategy for treating Alzheimer's disease.
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