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Gut microbiome mediates the causal relationship between chronic kidney disease and cognitive dysfunction: a mendelian
Lv Zhou1, Zhitian Wang1, Mengxue Wang1
1Department of neurology, Zhongda Hospital, School of Medicine, Jiangsu Provincial Key Laboratory of Brain Science and Medicine, Southeast University, Nanjing, 210009, China.
Physiology & Behavior
|August 17, 2025
Summary
Chronic kidney disease (CKD) causally impacts cognitive dysfunction. The gut microbiome mediates this relationship, offering potential therapeutic targets for cognitive decline.
Area of Science:
- Nephrology
- Neurology
- Microbiome Research
Background:
- The link between chronic kidney disease (CKD) and cognitive dysfunction remains debated.
- Mechanisms underlying CKD-induced cognitive impairment are not fully understood.
Purpose of the Study:
- To investigate the potential genetic causality between CKD and cognitive dysfunction.
- To explore the mediating role of the gut microbiome in this relationship using Mendelian randomization.
Main Methods:
- Utilized two-sample Mendelian randomization with 15 genome-wide association study (GWAS) datasets.
- Included datasets for CKD traits, cognitive traits, and gut microbiota.
Main Results:
- Established a causal link between CKD and cognitive dysfunction.
- Identified the gut microbiome as a pivotal mediator.
- Noted creatinine's positive correlation with cognitive performance and specific microbes like Eubacterium fissicatena group as potential influencers.
Conclusions:
- Confirmed a causal relationship between CKD and cognitive dysfunction.
- The gut microbiome acts as a significant mediator in this association.
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