Gastric Conditioning Before Ivor Lewis Esophagectomy for Cancer: Long-Term Outcomes From the APIL_2013 Pilot...

Gastric ischemic conditioning (GIC) before Ivor Lewis esophagectomy for cancer is associated with improved short-term outcomes, reducing the incidence and severity of anastomotic leakage (AL). The aim of this study was to explore the impact of GIC on long-term outcomes after esophageal surgery.

This randomized, single-center, controlled, parallel-group, pilot clinical trial included two groups: (1) GIC before Ivor Lewis esophagectomy and (2) surgery alone (SA). The primary endpoint was anastomotic stricture. Secondary endpoints included oral intake, reconstructive surgery following gastroplasty excision, chronic AL, airway fistulation, mortality, overall survival (OS), and recurrence rates at 1, 3, and 5 y.

Between 2015 and 2018, 38 patients were randomized and analyzed: 20 in the GIC group and 18 in the SA group. No cases of anastomotic stricture were observed. At the last follow-up, 90% of patients in the GIC group and 72.2% in the SA group achieved complete oral intake (P = 0.222). Among the four patients who required gastric conduit excision, only one underwent reconstructive surgery. Deaths due to chronic anastomotic leaks included one in the GIC group and two in the SA group. OS (GIC: 55% versus SA: 36%; P = 0.166) and disease-free survival (GIC: 50% versus SA: 36.8%; P = 0.411) were similar between the groups. Mortality due to disease recurrence was also comparable (GIC: 45% versus SA: 50%; P = 0.758). Patients without gastric conduit failure had significantly better survival (10% versus 55.8%; P = 0.018).

Long-term results of the APIL_2013 trial revealed comparable outcomes between groups for anastomotic stricture, airway fistulation, chronic AL, overall and disease-free survival, and recurrence rates. However, patients without gastric conduit failure have better OS.