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[Parathormone and calcitonin in men suffering from ischemic heart disease]
Insights
Men with coronary heart disease (CHD) show elevated parathyroid hormone (PTH) and calcitonin (CT) levels. These hormone changes are linked to angina pectoris attacks and acute myocardial infarction (AMI), suggesting a role in disease pathogenesis.
Area of Science:
- Endocrinology
- Cardiology
- Biochemistry
Background:
- Coronary heart disease (CHD) is associated with significant physiological changes.
- Parathyroid hormone (PTH) and calcitonin (CT) are key endocrine regulators.
- Understanding their role in cardiovascular events is crucial for patient management.
Purpose of the Study:
- To investigate basal serum concentrations of PTH and CT in men with CHD.
- To examine PTH and CT levels during angina pectoris attacks and acute myocardial infarction (AMI).
- To explore the pathogenetic role of these hormones and potential therapeutic implications.
Main Methods:
- Serum samples were collected from male patients with diagnosed CHD.
- Hormone levels (PTH and CT) were measured during interparoxysmal periods and angina attacks.
- Hormone levels were also assessed in patients with AMI, considering disease onset and stage.
Main Results:
- Elevated basal PTH and CT concentrations were observed in CHD patients during both angina attacks and interparoxysmal periods.
- During angina pectoris of effort, the highest CT levels were found on the day of the attack.
- In AMI, basal PTH was increased, particularly in the subacute stage; CT levels varied based on disease onset, being higher in sudden onset cases.
Conclusions:
- Shifts in parathyroid gland and thyroid C-cell function are implicated in the pathogenesis of CHD.
- The findings suggest a potential role for calcium antagonists and CT in treating myocardial infarction.
- Further research is warranted to elucidate the precise mechanisms and therapeutic efficacy.
Abstract:
It has been shown that in men with coronary heart disease (CHD), the basal concentrations of parathyroid hormone (PTH) and calcitonin (CT) in blood serum were increased both during an angina pectoris attack and the interparoxysmal period. During an angina pectoris attack, the highest CT concentration was detected in CHD patients with angina pectoris of effort on the day of the anginal attack. In acute myocardial infarction (AMI), the basal PTH level in the patients' blood serum was increased, particularly during the subacute disease stage. The blood serum CT content during AMI depended on the disease onset: in patients with a sudden disease onset, the parameter under study was increased, whereas in AMI patients with a history of angina pectoris, the CT concentration remained within normal. The authors discuss the pathogenetic role of the shifts in the function of the parathyroid glands and C cells of the thyroid during CHD and the possibility of the use of calcium antagonists and CT in the treatment of myocardial infarction.