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Updated: Sep 11, 2025

Structural Studies of Macromolecules in Solution using Small Angle X-Ray Scattering

Structural Studies of Macromolecules in Solution using Small Angle X-Ray Scattering

Published on: November 5, 2018

Snapshot of an intermediate structure.

Akira Shinohara^1,2

¹Institute for Protein Research, The University of Osaka, Osaka, Japan.

|August 18, 2025

Summary

This summary is machine-generated.

Detailed DNA structures were visualized using cryogenic electron microscopy. This study reveals the intermediate "D-loop" state during DNA strand exchange in homologous recombination.

Area of Science:

Molecular Biology
Structural Biology
Genetics

Background:

Homologous recombination is a fundamental biological process for DNA repair and genetic diversity.
Understanding intermediate states is crucial for elucidating the mechanism of recombination.

Keywords:

D-loop DNA repair RAD51 chromosomes gene expression homologous recombination homology search human molecular biophysics strand exchange structural biology

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