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Updated: Sep 11, 2025
02:28
Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
Published on: March 1, 2024
488
Generalized Pustular Psoriasis as a Systemic Inflammatory Disease: Experience With 38 Japanese Cases Over 15 Years at
Nobuyuki Kikuchi1, Misaki Kusano1, Toshiyuki Yamamoto1
1Dermatology, Fukushima Medical University, Fukushima, JPN.
Cureus
|August 18, 2025
Summary
Generalized pustular psoriasis (GPP) is a rare, systemic inflammatory condition. This study of 41 cases highlights GPP
Area of Science:
- Dermatology
- Immunology
- Genetics
Background:
- Pustular psoriasis is a rare subtype of psoriasis.
- It is classified into generalized and localized forms.
- Generalized pustular psoriasis (GPP) presents unique clinical challenges.
Purpose of the Study:
- To retrospectively analyze clinical characteristics, comorbidities, and treatment outcomes of pustular psoriasis.
- To investigate the expression of S100 proteins and IL-36 cytokines in GPP.
- To understand the systemic inflammatory nature of GPP.
Main Methods:
- Retrospective analysis of 41 pustular psoriasis cases over 15 years.
- Clinical data collection including demographics, history, comorbidities, and treatments.
- Immunohistochemistry for S100A8, S100A9, S100A15, and IL-36γ.
- Serum IL-36α and IL-36γ level measurement.
Main Results:
- 38 cases of GPP and 3 of localized pustular psoriasis were identified.
- Common comorbidities included hypertension, diabetes mellitus, and ischemic heart disease.
- High expression of S100A8/A9 and IL-36γ was observed in GPP lesions.
- Elevated serum IL-36α and IL-36γ levels correlated with active GPP.
Conclusions:
- GPP is a systemic inflammatory disease with significant comorbidities.
- S100 proteins and IL-36 cytokines are implicated in GPP pathogenesis.
- Further research into targeted therapies for GPP is warranted.
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