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Updated: Sep 11, 2025

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The Relationship Between Spinal Cord Atrophy and Cardiovascular Risk.

Tejen Shah1, Louis Salciccioli1, Seyed Zaidi1

  • 1Cardiology, SUNY Downstate Health Sciences University, Brooklyn, USA.

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PubMed
Summary
This summary is machine-generated.

Spinal cord atrophy is linked to cardiovascular risk factors like diabetes and hypertension. Lower spinal cord size may contribute to frailty and increased mortality risk.

Keywords:
atherosclerotic cardiovascular disease risk scorecardiovascular risk factorsdiabeteshypertensionspinal cord atrophy

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Area of Science:

  • Neurology
  • Cardiology
  • Geriatrics

Background:

  • Brain volume reduction is linked to cardiovascular (CV) risk factors.
  • Spinal cord (SC) atrophy may contribute to frailty, motor deficits, and mortality.
  • Understanding SC size in relation to CV risk is crucial.

Purpose of the Study:

  • To investigate the relationship between spinal cord size, age, and individual CV risk factors.
  • To determine the association between spinal cord size and overall cardiovascular risk.
  • To explore the impact of hypertension and diabetes on spinal cord dimensions.

Main Methods:

  • Retrospective review of 121 patients undergoing cervical SC MRI.
  • Exclusion of patients with known neurological or congenital diseases.
  • Calculation of Atherosclerotic Cardiovascular Disease (ASCVD) risk score and measurement of cross-sectional SC area (SCA) from C2-C6 levels.

Main Results:

  • Mean SCA showed inverse correlation with age and creatinine levels.
  • Stepwise decrease in SCA observed in patients with hypertension (HTN) and diabetes mellitus (DM).
  • DM was an independent predictor of lower SCA; ASCVD score moderately inversely correlated with SCA.

Conclusions:

  • Lower spinal cord area is associated with diabetes, possibly hypertension, and overall CV risk.
  • Spinal cord atrophy in patients with CV disease may contribute to frailty and mortality.
  • Findings highlight the link between cardiovascular health and spinal cord integrity.