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On the isolation of the thrombin inhibitor hirudin
Thrombosis Research
|November 15, 1985
Abstract:
A procedure for isolation of hirudin from crude preparations was described. By the use of ion exchange chromatography and affinity chromatography preparations were obtained with a specific activity of 10 to 15 antithrombin units/micrograms. Separation into several fractions with the same activity suggests the existence of isoinhibitors.