Related Experiment Video
Updated: Sep 11, 2025
06:59
Middle Cerebral Artery Occlusion Allowing Reperfusion via Common Carotid Artery Repair in Mice
Published on: January 23, 2019
17.9K
Association Between Migraine With and Without Aura and Cervical Artery Dissection
Robert J Trager1,2,3, Zachary A Cupler4,5, Timothy J Williamson6
1Chiropractic Medicine, Connor Whole Health, University Hospitals Cleveland Medical Center, Cleveland, USA.
Cureus
|August 18, 2025
Summary
Migraine with aura (MwA) and migraine without aura (MwoA) significantly increase the risk of cervical artery dissection (CeAD). This study found a similar increased incidence of CeAD in both migraine types compared to non-migraine controls.
Area of Science:
- Neurology
- Vascular Medicine
- Epidemiology
Background:
- Migraine without aura (MwoA) is a known risk factor for cervical artery dissection (CeAD).
- The association between migraine with aura (MwA) and CeAD is not well-established.
- Understanding these associations is crucial for patient risk assessment and management.
Purpose of the Study:
- To investigate the association between MwA and CeAD.
- To investigate the association between MwoA and CeAD.
- To compare the risk of CeAD in patients with MwA and MwoA against non-migraine controls.
Main Methods:
- Utilized de-identified US medical records (2014-2024) from TriNetX.
- Identified three cohorts: new MwA diagnosis, new MwoA diagnosis, and non-migraine controls.
- Employed propensity score matching to create two 1:1 matched cohorts (MwA vs. controls; MwoA vs. controls) totaling over 495,000 patients.
Main Results:
- Both MwA and MwoA were associated with a significantly increased risk of CeAD compared to controls.
- Patients with MwA showed a 5.91-fold increased risk (0.095% vs. 0.016%).
- Patients with MwoA showed a 3.60-fold increased risk (0.058% vs. 0.016%).
Conclusions:
- Both migraine with aura and migraine without aura are associated with a similarly increased incidence and risk of cervical artery dissection.
- Further research is warranted to explore the underlying pathophysiological mechanisms.
- Investigating potential mediating factors and the temporal relationship between migraine and CeAD is essential.
Related Concept Videos
01:26Arteries of the Head and Neck
1.8K
The human body's intricate network of arteries ensures that every organ system receives the necessary oxygen and nutrients for optimal function. The arterial network in the head and neck region is particularly complex, providing vital blood flow to the brain, eyes, and other critical structures. Prominent arteries in this region include the internal carotid arteries and the vertebral arteries.
The internal carotid arteries supply blood to the anterior portion of the cerebrum. They enter the...
The internal carotid arteries supply blood to the anterior portion of the cerebrum. They enter the...
1.8K
01:10The Arch of Aorta
1.0K
The coronary arteries, originating from the ascending aorta, bifurcate from two sinuses located within the ascending aorta. Positioned just above the aortic semilunar valve, these sinuses house essential aortic baroreceptors and chemoreceptors, crucial for maintaining cardiac function. The left coronary artery and the right coronary artery branch off from the left posterior and anterior aortic sinuses, respectively.
Encircling the heart, the coronary arteries form a ring-like structure before...
Encircling the heart, the coronary arteries form a ring-like structure before...
1.0K
01:21Aneurysm II: Clinical Manifestations and Diagnostic Studies
22
Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
22
01:30Aneurysm I: Introduction
25
An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...
25
01:21Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
34
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
34