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Biomolecular Detection employing the Interferometric Reflectance Imaging Sensor IRIS
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IRIS: Interpretable Retrieval-Augmented Classification for Long Interspersed Document Sequences.

Fengnan Li1, Elliot D Hill1, Shu Jiang1

  • 1Duke University / Durham, NC, USA.

Proceedings of the Conference. Association for Computational Linguistics. Meeting
|August 18, 2025
PubMed
Summary
This summary is machine-generated.

We introduce IRIS (Interpretable Retrieval-Augmented Classification for long Interspersed Document Sequences), a lightweight framework for efficient long document classification. IRIS excels in healthcare tasks, offering comparable performance and enhanced interpretability for complex datasets.

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Area of Science:

  • Natural Language Processing
  • Machine Learning
  • Computational Linguistics

Background:

  • Transformer models excel in document classification but face computational challenges with long texts.
  • Existing methods for long-text processing offer partial solutions but are insufficient for exceptionally lengthy sequences.

Purpose of the Study:

  • To propose IRIS (Interpretable Retrieval-Augmented Classification for long Interspersed Document Sequences), a novel, lightweight framework for efficient and interpretable long document classification.
  • To enable processing of arbitrarily long documents without increased computational cost, suitable for single-GPU training.

Main Methods:

  • IRIS segments documents into chunks and stores embeddings in a vector database.
  • Learnable query vectors retrieve relevant chunks, and a linear attention mechanism aggregates embeddings for classification.
  • The framework is designed for efficiency and interpretability, particularly for sparse, long-sequence data.

Main Results:

  • IRIS achieves performance comparable to baseline models on standard benchmarks.
  • The framework demonstrates superior performance in clinical note disease risk prediction tasks with extremely long and sparse documents.
  • IRIS provides global interpretability by summarizing key risk factors identified by the model.

Conclusions:

  • IRIS offers an efficient and interpretable solution for long document classification.
  • The framework shows significant potential in healthcare applications requiring both high performance and explainability.
  • IRIS addresses the limitations of current models in processing lengthy and complex textual data.