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Exploring macrophage polarization as a prognostic indicator for colorectal cancer: Unveiling the impact of metalloproteinase mutations

  • 0Clinical Gastroenterology, Universidade de Caxias do Sul, Caxias do Sul 95070-560, Rio Grande do Sul, Brazil.
World Journal of Clinical Cases +

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August 18, 2025

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August 18, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Metalloproteinase mutations in colorectal cancer did not alter M1/M2 macrophage infiltration but were linked to improved survival. Macrophage polarization showed no impact on prognosis or survival in this study.

Area Of Science

  • Immunology
  • Oncology
  • Molecular Biology

Background

  • Macrophages are key immune cells in the tumor microenvironment, with plasticity to promote or suppress cancer.
  • Macrophage polarization into M1 or M2 phenotypes has prognostic implications in colorectal neoplasms.
  • Targeting macrophage polarization is a potential therapeutic strategy for colorectal cancer.

Purpose Of The Study

  • To assess M1 and M2 macrophage infiltration in colorectal neoplasia.
  • To compare macrophage infiltration in patients with and without metalloproteinase mutations.
  • To identify prognostic factors and survival outcomes in colorectal cancer.

Main Methods

  • Two cohorts of 33 patients each with colorectal neoplasia (with/without metalloproteinase mutations) were studied.
  • Macrophage polarization was evaluated using M1 (iNOS) and M2 (CD163, CD206) markers.
  • Prognostic factors and survival data for colorectal cancer were analyzed.

Main Results

  • No significant differences in macrophage density were found based on metalloproteinase mutation status, age, gender, tumor region, staging, TILS, recurrence, or outcomes.
  • Macrophage polarization (M1/M2) did not correlate with colorectal cancer prognosis or survival.
  • Patients with metalloproteinase mutations exhibited a better survival rate.

Conclusions

  • Macrophage infiltration and polarization are not significantly associated with colorectal cancer prognosis or survival.
  • Metalloproteinase mutations may play a protective role in colorectal neoplasia, correlating with improved survival.
  • Further research into the role of metalloproteinase mutations in colorectal cancer is warranted.

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