New Tirucallane-Type Triterpenes Isolated from Commiphora oddurensis from Ethiopia with Anticancer Activity

Three new tirucallane-type triterpenes, tirucalla-7,24-diene-1β,3β-diol (oddurensinoid B), tirucalla-7-ene-1β,3β,25-triol (oddurensinoid H), and tirucalla-7, 24-diene-3β-ol-1-O-β-d-glucopyranoside (oddurensinoid K), were isolated from the resin of Commiphora oddurensis harvested from Ethiopia, Africa. Their structures were elucidated by one-dimensional (1D) NMR, two-dimensional (2D) NMR, and high-resolution mass spectrometry (HRMS). All three compounds were tested for their anticancer activity against HeLa cell lines. They all exhibit anticancer activity, with oddurensinoid H the most potent with IC₅₀ of 0.017 mg/mL (36.9 μM).