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Prognostic Value Of Positive Lymph Node Ratio, Tumor Deposit, And Perineural Invasion In Advanced Colorectal Signet-ring Cell Carcinoma.

Home
Prognostic Value Of Positive Lymph Node Ratio, Tumor Deposit, And Perineural Invasion In Advanced Colorectal Signet-ring Cell Carcinoma.

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Prognostic value of positive lymph node ratio, tumor deposit, and perineural invasion in advanced colorectal

Liang Chu¹, Han Wang², Tao Ling³

¹Department of Surgery, The Affiliated Yixing Hospital of Jiangsu University, Yixing, Jiangsu, China.

Frontiers in Molecular Biosciences

|August 18, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Positive lymph node ratio (LNR), tumor deposits (TD), and perineural invasion (PNI) are significant prognostic factors in advanced colorectal signet-ring cell carcinoma (SRCC). Combining these factors improves predictive accuracy for patient outcomes.

Keywords:

colorectal signet ring cell carcinoma lymph node ratio perineural invasion prognosis tumor deposit

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Area of Science:

Oncology
Gastroenterology
Surgical Pathology

Background:

Advanced colorectal signet-ring cell carcinoma (SRCC) presents unique challenges in prognosis.
Accurate prediction of outcomes is crucial for effective patient management.

Purpose of the Study:

To evaluate the prognostic significance of lymph node ratio (LNR), tumor deposits (TD), and perineural invasion (PNI) in advanced colorectal SRCC.
To develop a predictive model for improved outcome assessment.

Main Methods:

Multicenter retrospective cohort study of 677 patients with advanced colorectal SRCC.
Kaplan-Meier analysis and multivariable Cox proportional hazards models were used.
A prognostic nomogram was developed and validated.

Main Results:

High LNR, TD positivity, and PNI positivity were associated with poorer cancer-specific survival (CSS) and overall survival (OS).
T stage, M stage, TD, CEA, chemotherapy, and LNR were identified as independent prognostic factors.
The combined assessment of LNR, TD, and PNI significantly enhanced predictive performance, contributing substantially to OS and CSS.

Conclusions:

LNR, TD, and PNI are valuable prognostic indicators for advanced colorectal SRCC.
Combined analysis of these factors offers superior prognostic predictive value compared to individual assessment.