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Macrophages in rosacea: pathogenesis and therapeutic potential
Xiaolin Wang1, Huanyu Shi1, Xueli Li1
1Department of Dermatology, Chengdu Second People's Hospital, Chengdu, Sichuan, China.
Frontiers in Immunology
|August 18, 2025
Summary
Macrophages are key players in rosacea, influencing immune responses and inflammation. Understanding their role offers new therapeutic targets for this chronic skin condition.
Area of Science:
- Dermatology
- Immunology
- Cell Biology
Background:
- Rosacea is a chronic inflammatory skin condition affecting the central face.
- The exact causes of rosacea are not fully understood.
- Macrophages are critical immune cells involved in inflammation.
Purpose of the Study:
- To review the role of macrophages in rosacea pathogenesis.
- To explore macrophages as potential therapeutic targets for rosacea.
Main Methods:
- Systematic literature search of PubMed and Web of Science.
- Keywords: rosacea, macrophage.
- Inclusion of 121 relevant articles.
Main Results:
- Macrophages significantly contribute to rosacea pathogenesis.
- They regulate immune responses, angiogenesis, oxidative stress, and fibrosis.
- Their potential as therapeutic targets is highlighted.
Conclusions:
- Macrophages play a multifaceted role in rosacea.
- Further research is needed to elucidate specific mechanisms.
- Targeting macrophages may offer novel treatment strategies for rosacea.
